Ireland winger Craig Gilroy is set to make his first Test start after being named in the starting side for Saturday's crunch clash against Argentina at Dublin's Lansdowne Road.
Gilroy, 21, replaces Ulster colleague Andrew Trimble in the only change to the Ireland side beaten 16-12 by South Africa a fortnight ago.
The encounter will be Ireland's first full Test since that defeat by the Springboks, with Gilroy rewarded after impressing with three tries in the intervening non-Test 53-0 rout of Fiji at Thomond Park last weekend.
Argentina, meanwhile, recalled fullback Juan Martin Hernandez in one of four changes to their side.
The Pumas, looking to bounce back from last weekend's defeat by France, have brought Racing Metro back Hernandez in to replace Lucas Gonzalez Amorosino.
Hernandez is joined in the backs by Exeter's Gonzalo Camacho and Santiago Fernandez.
An injury to Horacio Agulla led to Camacho's return, with Fernandez replacing Gonzalo Tiesi and Marcelo Bosch moving to outside centre.
Up front Maximiliano Bustos is set to make his debut in place of suspended prop Juan Figallo.
This weekend's Test has a wider importance for both sides, with the winner guaranteed a place in the top eight of the International Rugby Board rankings used to determine the seedings for next month's 2015 World Cup draw.
The loser, by contrast, will slip into the third tier of nations for next month's draw in London and so face the daunting prospect of being placed in a pool with two higher ranked countries, with only two from each group qualifying for the quarter-finals, at the next World Cup in England in three years' time.
Ireland go into the weekend on the back of a five-match losing run, their worst sequence in Tests for 14 years and are missing several injured senior players including Brian O'Driscoll, Paul O'Connell, Rory Best, Stephen Ferris, Sean O'Brien and Rob Kearney.
Argentina, beaten 39-22 by France in Lille last weekend, will be looking to add another scalp this tour on Saturday following their impressive 26-12 victory over Six Nations Grand Slam champions Wales in Cardiff on November 10.
Simon Zebo, Tommy Bowe, Keith Earls, Gordon D'Arcy, Craig Gilroy, Jonathan Sexton, Conor Murray, Jamie Heaslip (capt), Chris Henry, Peter O'Mahony, Mike McCarthy, Donnacha Ryan, Mike Ross, Richardt Strauss, Cian Healy. Replacements: Sean Cronin, David Kilcoyne, Michael Bent, Donncha O'Callaghan, Iain Henderson, Eoin Reddan, Ronan O'Gara, Fergus McFadden.
Juan Martin Hernandez, Gonzalo Camacho, Marcelo Bosch, Santiago Fernandez, Juan Imhoff, Nicolas Sanchez, Martin Landajo, Leonardo Senatore, Juan Manuel Leguizamon, Juan Martin Fernandez Lobbe (capt), Julio Farias Caballo, Manuel Carizza, Maximiliano Bustos, Eusebio Guinazu, Marcos Ayerza. Replacements: Agustin Creevy, Nahuel Lobo, Francisco Gomez Kodela, Tomas Vallejos, Tomas Leonardi, Nicolas Vergallo, Gonzalo Tiesi, Manuel Montero.