Australian No.1 Cameron Pilley is safely through to the second round of the $US185,000 ($A181,450) US Open squash championship in Philadelphia.

Pilley only needed half an hour to dispatch South African qualifier Stephen Coppinger 11-0 11-5 11-5 to book a clash with the eighth-seeded Egyptian Mohamed El Shorbagy on Tuesday (AEST).

Fellow Australians Ryan Cuskelly and Matt Karwalski have fallen one win short of qualifying for the main draw.

Ninth-seeded Cuskelly lost 11-4 11-9 7-11 11-7 to Egyptian eighth seed Karim Abdel Gawad in his final-round qualifying match and Canadian Shahier Razik beat Karwalski 11-5 6-11 11-7 11-5.

Australian women's No.1 Kasey Brown, who shocked world No.1 Nicol David and the then-fourth-ranked Madeline Perry en route to last year's final, opens her campaign on Tuesday against Hong Kong's sixth seed Annie Au.

Rachael Grinham launches her title bid against third-seed Englishwoman Jenny Duncalf.