With Rafael Nadal down and Roger Federer out, Novak Djokovic and Andy Murray will carry the hopes of tennis's Big Four on so-called Super Saturday at the US Open.
For the first time in eight years and 34 majors, Federer and Nadal are both missing from a grand slam semi-final line-up.
The absence of the two tennis titans leaves defending champion Djokovic and major-less Murray on a final collision course in New York.
Officials, fans and US broadcasters sure hope so anyway - a Tomas Berdych-David Ferrer title match won't quite cut it.
Djokovic faces fourth seed Ferrer in his semi after out-muscling 2009 champion Juan Martin del Potro 6-2 7-6 (7-3) 6-4 in a punishing three-hour quarter-final on Thursday night.
Victory vaulted the second seed into his 10th successive grand slam semi-final, placing the 25-year-old alongside legends Rod Laver and Ivan Lendl in second place behind Federer for most consecutive last-four appearances at a major.
The win also avenged Serbia's Olympic flagbearer's bronze-medal playoff loss to del Potro at last month's London Games.
"It could have gone really either way," Djokovic said.
"I didn't expect anything less. Del Potro is a grand slam winner; he loves playing here.
"I was very much aware of how good he is and how powerful he can play and how dangerous he can be on this surface.
"He loves playing on the big stage."
Even with no Federer or Nadal in sight, Djokovic said it would be dangerous to presume he and Murray would automatically set up a 2011 Australian Open final rematch.
"I take it very seriously whoever I have to face in the next round," said the world No.2.
"You have Murray, Berdych, Ferrer, myself, we're all top-10 players.
"For maybe some people it was surprising to see Roger lose because he's been so consistent and dominant a player in the last couple of years.
"He's always expected to get to at least semi-finals of every grand slam.
"But, look, Berdych deserved to win. He came up with incredible tennis. I have never seen him play that well.
"This is tennis."
Ferrer rallied from a service break down in the deciding set to reel in Djokovic's Davis Cup teammate Janko Tipsarevic 6-3 6-7 (5-7) 2-6 6-3 7-6 (7-4) in his four-hour, 13-minute quarter-final.
"It was a lottery in the fifth set," Ferrer said after matching his 2007 run to the Open semi-finals.
Ferrer also made the last four at Roland Garros, beating Murray en route, and having also beaten Djokovic on five previous occasions, the Spaniard fears no one.
Nor does he care if he's rated a genuine contender or not.
"This season was the best of all my career," the 30-year-old said.
"I don't know why. Maybe because I don't have never in my career important injuries. I am playing with a lot of confidence.
"I am older I don't have too much pressure as when I was 20 years old.
"Of course people know more Roger, Andy Murray, Djokovic, Del Potro, because they won grand slam or important trophies.
"Not me - but I don't care. It's perfect for me."
Third-seeded Murray, looking to break through after four grand slam final defeats, and big-hitting Berdych booked their semi-final meeting on Wednesday.