Wales caretaker coach Rob Howley will field three debutants for this weekend's clash against the Barbarians in Cardiff.
Howley has handed Test debuts to Scarlets full-back Liam Williams and prop Rhodri Jones, and teenage Cardiff wing Harry Robinson.
It could also be a landmark occasion for Robinson's Blues teammate Martyn Williams, who will win his 100th cap if he comes off the bench against a Barbarians team who beat Ireland on Tuesday but lost to England on the weekend.
Williams is set to join Welsh centurions Stephen Jones and Gareth Thomas by reaching the three-figure landmark.
Scarlets hooker Matthew Rees will captain a Wales side that includes locks Alun Wyn Jones and Ian Evans, plus number eight Ryan Jones.
There are returns to the Test arena for Ospreys centre Andrew Bishop and fly-half Dan Biggar, who both played key roles in last Sunday's Celtic League title-clinching victory over European champions Leinster in Dublin.
The bench also includes uncapped Scarlets centre Adam Warren for Wales' final game before embarking on a three-Test tour to Australia.
"We have picked a side on form, with an eye on bringing players through for the future, but very much with the intention of getting the summer campaign off to a winning start," Howley said.
Wales team to play the Barbarians at the Millennium Stadium on Saturday:
Liam Williams (Scarlets); Harry Robinson (Cardiff Blues), Andrew Bishop (Ospreys), James Hook (Perpignan), Aled Brew (Newport Gwent Dragons); Dan Biggar (Ospreys), Lloyd Williams (Cardiff Blues); Rhys Gill (Saracens), Matthew Rees (Scarlets, capt), Rhodri Jones (Scarlets), Alun Wyn Jones (Ospreys), Ian Evans (Ospreys), Josh Turnbull (Scarlets), Justin Tipuric (Ospreys), Ryan Jones (Ospreys)
Replacements: Richard Hibbard (Ospreys), Paul James (Ospreys), Aaron Shingler (Scarlets), Martyn Williams (Cardiff Blues), Rhys Webb (Ospreys), Adam Warren (Scarlets), Will Harries (Newport Gwent Dragons)