World No.1 Novak Djokovic begins his bid for a historic grand slam on Monday when he tackles Italian claycourter Potito Starace in the French Open first round.
The top seed is just seven wins away from becoming only the third man to hold all four majors at the same time.
But the Wimbledon, US Open and Australian Open champion has never made a final in Paris, falling at the semi-finals on three occasions.
He also has Roger Federer in his half of the draw where the great Swiss looms as a potential semi-final opponent.
Federer, the holder of a record 16 grand slam titles, was the champion at Roland Garros in 2009, and he also starts his campaign on Monday against Germany's Tobias Kamke.
Defending women's champion Li Na of China is second match on Court Philippe Chatrier where she faces Romania's Sorana Cirstea.
Top seed and world No.1 Victoria Azarenka, the Australian Open champion, begins proceedings on the main court against Alberta Brianti of Italy.
Former men's No.1 Lleyton Hewitt of Australia is also in action against Slovenia's Blaz Kavcic.
The former Wimbledon and US Open champion will take to Court Seven with two screws and a metal plate locked permanently in place in the big toe on his left foot after radical surgery to prolong his career.
Hewitt, now ranked 175, has had only two weeks of practice ahead of his first-round match and, if he gets past Kavcic, his next opponent could be Djokovic.
Other Australians in action on day two are headlined by 25th seed Bernard Tomic who takes on Austria's Andreas Haider-Maurer, while Matthew Ebden plays his first round against 24-seeded German Philipp Kohlschreiber.